FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

Fat-induced hepatic insulin resistance plays a key role in the pathogenesis of type 2 diabetes in obese individuals. Although PKC and inflammatory pathways have been implicated in fat-induced hepatic insulin resistance, the sequence of events leading to impaired insulin signaling is unknown. We used...

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Autori principali: Pereira, Sandra, Park, Edward, Mori, Yusaku, Haber, C. Andrew, Han, Ping, Uchida, Toyoyoshi, Stavar, Laura, Oprescu, Andrei I., Koulajian, Khajag, Ivovic, Alexander, Yu, Zhiwen, Li, Deling, Bowman, Thomas A., Dewald, Jay, El-Benna, Jamel, Brindley, David N., Gutierrez-Juarez, Roger, Lam, Tony K. T., Najjar, Sonia M., McKay, Robert A., Bhanot, Sanjay, Fantus, I. George, Giacca, Adria
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4080148/
https://ncbi.nlm.nih.gov/pubmed/24824652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00436.2013
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