Multiple origins of replication in the dihydrofolate reductase amplicons of a methotrexate-resistant chinese hamster cell line.

We recently showed that replication initiates in the early S period at two closely spaced zones in the 240-kilobase (kb) dihydrofolate reductase (DHFR) amplicon of the methotrexate-resistant Chinese hamster ovary cell line CHOC 400. Both of these initiation loci (ori-beta and ori-gamma) have previou...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Ma, C, Leu, T H, Hamlin, J L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2320001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.4.1338-1346.1990
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