The Hedgehog Receptor Patched1 in T Cells Is Dispensable for Adaptive Immunity in Mice

Hedgehog (Hh) signaling modulates T cell development and function but its exact role remains a matter of debate. To further address this issue we made use of conditional knock-out mice in which the Hh receptor Patched1 (Ptch) is inactivated in the T cell lineage. Thymocyte development was moderately...

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Main Authors: Michel, Kai D., Uhmann, Anja, Dressel, Ralf, van den Brandt, Jens, Hahn, Heidi, Reichardt, Holger M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620050/
https://ncbi.nlm.nih.gov/pubmed/23577186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061034
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