Enhanced Glucocorticoid Receptor Signaling in T Cells Impacts Thymocyte Apoptosis and Adaptive Immune Responses

To study the effect of enhanced glucocorticoid signaling on T cells, we generated transgenic rats overexpressing a mutant glucocorticoid receptor with increased ligand affinity in the thymus. We found that this caused massive thymocyte apoptosis at physiological hormone levels, which could be revers...

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Detalhes bibliográficos
Main Authors: Brandt, Jens van den, Lühder, Fred, McPherson, Kirsty G., de Graaf, Katrien L., Tischner, Denise, Wiehr, Stefan, Herrmann, Thomas, Weissert, Robert, Gold, Ralf, Reichardt, Holger M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2007
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1864890/
https://ncbi.nlm.nih.gov/pubmed/17322387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.060804
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