Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole–Imidazole Polyamide

[Image: see text] The zinc finger protein EVI1 is causally associated with acute myeloid leukemogenesis, and inhibition of its function with a small molecule therapeutic may provide effective therapy for EVI1-expressing leukemias. In this paper we describe the development of a pyrrole–imidazole poly...

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Hoofdauteurs: Zhang, Yi, Sicot, Géraldine, Cui, Xiaohui, Vogel, Marion, Wuertzer, Charles A., Lezon-Geyda, Kimberly, Wheeler, John, Harki, Daniel A., Muzikar, Katy A., Stolper, Daniel A., Dervan, Peter B., Perkins, Archibald S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619939/
https://ncbi.nlm.nih.gov/pubmed/22039883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200962u
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