Methylation of SUV39H1 by SET7/9 results in heterochromatin relaxation and genome instability

Suppressor of variegation 3–9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well...

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Detalhes bibliográficos
Main Authors: Wang, Donglai, Zhou, Jingyi, Liu, Xiangyu, Lu, Danyu, Shen, Changchun, Du, Yipeng, Wei, Fu-Zheng, Song, Boyan, Lu, Xiaopeng, Yu, Yu, Wang, Lina, Zhao, Ying, Wang, Haiying, Yang, Yang, Akiyama, Yoshimitsu, Zhang, Hongquan, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3619320/
https://ncbi.nlm.nih.gov/pubmed/23509280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216596110
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