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Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy
Rifampicin and isoniazid co–therapy frequently causes liver injury in humans. A pregnane X receptor–humanized mouse model revealed that rifampicin and isoniazid co–treatment causes accumulation of protoporphyrin IX, an endogenous hepatotoxin, in the liver via a pregnane X receptor–mediated alteratio...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3618537/ https://ncbi.nlm.nih.gov/pubmed/23475203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3104 |
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