Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co–therapy

Rifampicin and isoniazid co–therapy frequently causes liver injury in humans. A pregnane X receptor–humanized mouse model revealed that rifampicin and isoniazid co–treatment causes accumulation of protoporphyrin IX, an endogenous hepatotoxin, in the liver via a pregnane X receptor–mediated alteratio...

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Bibliografiske detaljer
Main Authors: Li, Feng, Lu, Jie, Cheng, Jie, Wang, Laiyou, Matsubara, Tsutomu, Csanaky, Iván L., Klaassen, Curtis D., Gonzalez, Frank J., Ma, Xiaochao
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618537/
https://ncbi.nlm.nih.gov/pubmed/23475203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3104
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