Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-β (Aβ) production, which is involved in AD pathogenesis, by inhibiting β-secretase (BACE1) activity. Contactin 5 (CNTN5) has also been implicated in the development o...

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Bibliographic Details
Main Authors: Whitehouse, Isobel J., Miners, J. Scott, Glennon, Elizabeth B. C., Kehoe, Patrick G., Love, Seth, Kellett, Katherine A. B., Hooper, Nigel M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618446/
https://ncbi.nlm.nih.gov/pubmed/23577068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059554
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