Prion Protein Is Decreased in Alzheimer's Brain and Inversely Correlates with BACE1 Activity, Amyloid-β Levels and Braak Stage

The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-β (Aβ) production, which is involved in AD pathogenesis, by inhibiting β-secretase (BACE1) activity. Contactin 5 (CNTN5) has also been implicated in the development o...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Whitehouse, Isobel J., Miners, J. Scott, Glennon, Elizabeth B. C., Kehoe, Patrick G., Love, Seth, Kellett, Katherine A. B., Hooper, Nigel M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618446/
https://ncbi.nlm.nih.gov/pubmed/23577068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059554
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares