Pregnancy-associated Plasma Protein A (PAPP-A) Modulates the Early Developmental Rate in Zebrafish Independently of Its Proteolytic Activity

Pregnancy-associated plasma protein-A (PAPP-A) is a large metalloproteinase specifically cleaving insulin-like growth factor (IGF) binding proteins, causing increased IGF bioavailability and, hence, local regulation of IGF receptor activation. We have identified two highly conserved zebrafish homolo...

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Detalhes bibliográficos
Main Authors: Kjaer-Sorensen, Kasper, Engholm, Ditte H., Kamei, Hiroyasu, Morch, Maria G., Kristensen, Anisette O., Zhou, Jianfeng, Conover, Cheryl A., Duan, Cunming, Oxvig, Claus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3617297/
https://ncbi.nlm.nih.gov/pubmed/23430244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.426304
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