Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions

Recent experiments provided controversial observations that either parallel or non-parallel G-quadruplex exists in molecularly crowded buffers that mimic cellular environment. Here, we used laser tweezers to mechanically unfold structures in a human telomeric DNA fragment, 5′-(TTAGGG)(4)TTA, along t...

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Hlavní autoři: Dhakal, Soma, Cui, Yunxi, Koirala, Deepak, Ghimire, Chiran, Kushwaha, Saurabh, Yu, Zhongbo, Yangyuoru, Philip M., Mao, Hanbin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616730/
https://ncbi.nlm.nih.gov/pubmed/23396442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt038
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