Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD

Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the endoplasmic reticulum–resident rhomboid protease RHBDL4 facilitates ERAD by recognizing and cleaving...

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Bibliographic Details
Main Authors:	Greenblatt, Ethan J, Olzmann, James A, Kopito, Ron R
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3616633/ https://ncbi.nlm.nih.gov/pubmed/23037595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2398
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Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD

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