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Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

The degradation of misfolded secretory proteins is ultimately mediated by the ubiquitin-proteasome system in the cytoplasm, therefore endoplasmic reticulum–associated degradation (ERAD) substrates must be dislocated across the ER membrane through a process driven by the AAA ATPase p97/VCP. Derlins r...

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Main Authors: Greenblatt, Ethan J, Olzmann, James A, Kopito, Ron R
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196324/
https://ncbi.nlm.nih.gov/pubmed/21909096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2111
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