Derlin-1 Regulates Mutant VCP-Linked Pathogenesis and Endoplasmic Reticulum Stress-Induced Apoptosis

Mutations in VCP (Valosin-containing protein), an AAA ATPase critical for ER-associated degradation, are linked to IBMPFD (Inclusion body myopathy with Paget disease and frontotemporal dementia). Using a Drosophila IBMPFD model, we have identified the ER protein Derlin-1 as a modifier of pathogenic...

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Detalhes bibliográficos
Main Authors: Liang, Cyong-Jhih, Chang, Ya-Chu, Chang, Henry C., Wang, Chung-Kang, Hung, Yu-Chien, Lin, Ying-Er, Chan, Chia-Ching, Chen, Chun-Hong, Chang, Hui-Yun, Sang, Tzu-Kang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4177747/
https://ncbi.nlm.nih.gov/pubmed/25255315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004675
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