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Lipid Droplet Formation Is Dispensable for Endoplasmic Reticulum-associated Degradation

Proteins that fail to fold or assemble in the endoplasmic reticulum (ER) are destroyed by cytoplasmic proteasomes through a process known as ER-associated degradation. Substrates of this pathway are initially sequestered within the ER lumen and must therefore be dislocated across the ER membrane to...

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Bibliographic Details
Main Authors: Olzmann, James A., Kopito, Ron R.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151032/
https://ncbi.nlm.nih.gov/pubmed/21693705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.266452
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