Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks

Morphological analysis of mitotic chromosomes is used to detect mutagenic chemical compounds and to estimate the dose of ionizing radiation to be administered. It has long been believed that chromosomal breaks are always associated with double-strand breaks (DSBs). We here provide compelling evidenc...

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Detalhes bibliográficos
Main Authors: Fujita, Mari, Sasanuma, Hiroyuki, Yamamoto, Kimiyo N., Harada, Hiroshi, Kurosawa, Aya, Adachi, Noritaka, Omura, Masato, Hiraoka, Masahiro, Takeda, Shunichi, Hirota, Kouji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616066/
https://ncbi.nlm.nih.gov/pubmed/23573231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060043
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