Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

Cultured NIH-3T3 cells were transfected with cDNA constructs encoding human epidermal growth factor-receptor (EGF-R)* and two deletion mutants in the extracellular portion of the receptor molecule. One mutant is devoid of 124 amino-terminal amino acids, and the other lacks 76 residues. Mutant recept...

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Bibliographische Detailangaben
Hauptverfasser: Lax, I, Bellot, F, Honegger, A M, Schmidt, A, Ullrich, A, Givol, D, Schlessinger, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1990
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC361439/
https://ncbi.nlm.nih.gov/pubmed/2100196
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