Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.
Cultured NIH-3T3 cells were transfected with cDNA constructs encoding human epidermal growth factor-receptor (EGF-R)* and two deletion mutants in the extracellular portion of the receptor molecule. One mutant is devoid of 124 amino-terminal amino acids, and the other lacks 76 residues. Mutant recept...
Gespeichert in:
| Veröffentlicht in: | Cell Regul |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Cell Biology
1990
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2100196/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.1.2.173 |
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