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Domain deletion in the extracellular portion of the EGF-receptor reduces ligand binding and impairs cell surface expression.

Cultured NIH-3T3 cells were transfected with cDNA constructs encoding human epidermal growth factor-receptor (EGF-R)* and two deletion mutants in the extracellular portion of the receptor molecule. One mutant is devoid of 124 amino-terminal amino acids, and the other lacks 76 residues. Mutant recept...

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Udgivet i:Cell Regul
Principais autores: Lax, I, Bellot, F, Honegger, A M, Schmidt, A, Ullrich, A, Givol, D, Schlessinger, J
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361439/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2100196/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.1.2.173
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