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The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

Quantitative epidermal growth factor (EGF)-binding experiments have shown that the EGF-receptor (EGFR) is displayed on the surface of intact cells in two forms, a minority of high-affinity and a majority of low-affinity EGFRs. On the basis of the three-dimensional structure of the extracellular liga...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mattoon, Dawn, Klein, Peter, Lemmon, Mark A., Lax, Irit, Schlessinger, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327118/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732693/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307286101
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