The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function
Quantitative epidermal growth factor (EGF)-binding experiments have shown that the EGF-receptor (EGFR) is displayed on the surface of intact cells in two forms, a minority of high-affinity and a majority of low-affinity EGFRs. On the basis of the three-dimensional structure of the extracellular liga...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327118/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307286101 |
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