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Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast
The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3′ end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Cold Spring Harbor Laboratory Press
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613610/ https://ncbi.nlm.nih.gov/pubmed/23468430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.212738.112 |
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