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Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast

The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3′ end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage...

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Detalhes bibliográficos
Main Authors: Kannan, Ram, Hartnett, Sean, Voelker, Rodger B., Berglund, J. Andrew, Staley, Jonathan P., Baumann, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613610/
https://ncbi.nlm.nih.gov/pubmed/23468430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.212738.112
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