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TDP-43 toxicity: the usefulness of “junk”
Loss of the lariat debranching enzyme Dbr1 is found to repress TDP-43 toxicity. The accumulated intronic lariat RNAs, which are normally degraded after splicing, likely act as decoys to sequester TDP-43 away from binding to and disrupting function of other RNAs.
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3612973/ https://ncbi.nlm.nih.gov/pubmed/23192178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2473 |
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