Targeting Inhibition of Fibroblast Activation Protein-α and Prolyl Oligopeptidase Activities on Cells Common to Metastatic Tumor Microenvironments

Fibroblast activation protein (FAP), a membrane prolyl-specific proteinase with both dipeptidase and endopeptidase activities, is overexpressed by reactive stromal fibroblasts during epithelial-derived cancer growth. FAP digests extracellular matrix as tissue is remodeled during cancer expansion and...

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Bibliographic Details
Main Authors: Christiansen, Victoria J, Jackson, Kenneth W, Lee, Kyung N, Downs, Tamyra D, McKee, Patrick A
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612908/
https://ncbi.nlm.nih.gov/pubmed/23555181
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