A phase 1 study to evaluate the effect of dolutegravir on renal function via measurement of iohexol and para-aminohippurate clearance in healthy subjects

AIM: Dolutegravir (DTG; S/GSK1349572) is under clinical development as a once daily, unboosted integrase inhibitor for the treatment of HIV infection. The effect of DTG on glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and creatinine clearance (CL(cr)) was evaluated in 34 heal...

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Detalhes bibliográficos
Main Authors: Koteff, Justin, Borland, Julie, Chen, Shuguang, Song, Ivy, Peppercorn, Amanda, Koshiba, Takaaki, Cannon, Courtney, Muster, Heather, Piscitelli, Stephen C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Clinical Trials
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612717/
https://ncbi.nlm.nih.gov/pubmed/22905856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2012.04440.x
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