Pharmacokinetics of Single-Dose Dolutegravir in HIV-Seronegative Subjects With Moderate Hepatic Impairment Compared to Healthy Matched Controls

This study evaluated dolutegravir pharmacokinetics (PK) in subjects with moderate hepatic impairment compared to matched, healthy controls. In this open-label, parallel-group study, eight adult subjects with moderate hepatic impairment (Child-Pugh Score 7–9) and eight healthy subjects matched for ge...

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Bibliographische Detailangaben
Veröffentlicht in:Clin Pharmacol Drug Dev
Hauptverfasser: Song, Ivy H, Borland, Julie, Savina, Paul M, Chen, Shuguang, Patel, Parul, Wajima, Toshihiro, Peppercorn, Amanda F, Piscitelli, Stephen C
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2013
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467250/
https://ncbi.nlm.nih.gov/pubmed/26097786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.55
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