Pharmacokinetics of Single-Dose Dolutegravir in HIV-Seronegative Subjects With Moderate Hepatic Impairment Compared to Healthy Matched Controls

This study evaluated dolutegravir pharmacokinetics (PK) in subjects with moderate hepatic impairment compared to matched, healthy controls. In this open-label, parallel-group study, eight adult subjects with moderate hepatic impairment (Child-Pugh Score 7–9) and eight healthy subjects matched for ge...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Drug Dev
Main Authors: Song, Ivy H, Borland, Julie, Savina, Paul M, Chen, Shuguang, Patel, Parul, Wajima, Toshihiro, Peppercorn, Amanda F, Piscitelli, Stephen C
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467250/
https://ncbi.nlm.nih.gov/pubmed/26097786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.55
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