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Effect of Food on the Pharmacokinetics of the Integrase Inhibitor Dolutegravir
Healthy subjects received dolutegravir at 50 mg in a single-dose crossover study while they were in the fasted state or with low-, moderate-, or high-fat meals. Food increased dolutegravir exposure and reduced the rate of absorption. The area under the concentration-time curve from 0 h to infinity (...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3294934/ https://ncbi.nlm.nih.gov/pubmed/22183173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05739-11 |
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