Effect of Food on the Pharmacokinetics of the Integrase Inhibitor Dolutegravir

Healthy subjects received dolutegravir at 50 mg in a single-dose crossover study while they were in the fasted state or with low-, moderate-, or high-fat meals. Food increased dolutegravir exposure and reduced the rate of absorption. The area under the concentration-time curve from 0 h to infinity (...

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Bibliographic Details
Main Authors: Song, Ivy, Borland, Julie, Chen, Shuguang, Patel, Parul, Wajima, Toshihiro, Peppercorn, Amanda, Piscitelli, Stephen C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294934/
https://ncbi.nlm.nih.gov/pubmed/22183173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05739-11
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