The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates

TDP-43 is the major pathological protein identified in the cellular inclusions in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The pathogenic forms of TDP-43 are processed C-terminal fragments containing a truncated RNA-recognition motif (RRM2) and a glycine-rich region. Alth...

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Detalhes bibliográficos
Main Authors: Wang, Yi-Ting, Kuo, Pan-Hsien, Chiang, Chien-Hao, Liang, Jhe-Ruei, Chen, Yun-Ru, Wang, Shuying, Shen, James C. K., Yuan, Hanna S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610977/
https://ncbi.nlm.nih.gov/pubmed/23372158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.438564
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