Hyperphosphorylation as a Defense Mechanism to Reduce TDP-43 Aggregation

Several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are characterized by inclusion bodies formed by TDP-43 (TDP). We established cell and transgenic Drosophila models expressing TDP carboxyl ter...

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Detalhes bibliográficos
Main Authors: Li, Huei-Ying, Yeh, Po-An, Chiu, Hsiu-Chiang, Tang, Chiou-Yang, Tu, Benjamin Pang-hsien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151276/
https://ncbi.nlm.nih.gov/pubmed/21850253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023075
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