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BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G(1) Phase of the Cell Cycle

Quality control of DNA double-strand break (DSB) repair is vital in preventing mutagenesis. Non-homologous end-joining (NHEJ), a repair process predominant in the G(1) phase of the cell cycle, rejoins DSBs either accurately or with errors, but the mechanisms controlling its fidelity are poorly under...

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Detalhes bibliográficos
Main Authors: Jiang, Guochun, Plo, Isabelle, Wang, Tong, Rahman, Mohammad, Cho, Ju Hwan, Yang, Eddy, Lopez, Bernard S., Xia, Fen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610969/
https://ncbi.nlm.nih.gov/pubmed/23344954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.412650
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