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Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80

BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although mounting evidence has indicated that BRCA1 participates in DNA double-strand break (DSB) repair pathways, its precise mechanism is still unclear. Here, we analyzed the in situ response of BRCA1 at DSBs produc...

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Detalhes bibliográficos
Main Authors: Wei, Leizhen, Lan, Li, Hong, Zehui, Yasui, Akira, Ishioka, Chikashi, Chiba, Natsuko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593434/
https://ncbi.nlm.nih.gov/pubmed/18936166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01075-08
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