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Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80

BRCA1 is the first susceptibility gene to be linked to breast and ovarian cancers. Although mounting evidence has indicated that BRCA1 participates in DNA double-strand break (DSB) repair pathways, its precise mechanism is still unclear. Here, we analyzed the in situ response of BRCA1 at DSBs produc...

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Bibliografische gegevens
Hoofdauteurs: Wei, Leizhen, Lan, Li, Hong, Zehui, Yasui, Akira, Ishioka, Chikashi, Chiba, Natsuko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593434/
https://ncbi.nlm.nih.gov/pubmed/18936166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01075-08
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