Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair

The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is poorly defined. A growing body of evidence suggests that promotion of DNA double-strand break repair by homologous recombination (HR) may be the means by which BRCA1 maintain...

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Detalhes bibliográficos
Main Authors: Zhang, Junran, Willers, Henning, Feng, Zhihui, Ghosh, Jagadish C., Kim, Sang, Weaver, David T., Chung, Jay H., Powell, Simon N., Xia, Fen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC343805/
https://ncbi.nlm.nih.gov/pubmed/14701743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.2.708-718.2004
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