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Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

Focal Adhesion Kinase (FAK) is essential for cell migration and plays an important role in tumor metastasis. However, the complex intermolecular and intramolecular interactions that regulate FAK activity at the focal adhesion remain unresolved. We have engineered a toolbox of FRET sensors that retai...

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Autori principali: Ritt, Michael, Guan, Jun Lin, Sivaramakrishnan, Sivaraj
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610962/
https://ncbi.nlm.nih.gov/pubmed/23393139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421164
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