Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

We have investigated a role for the amino-terminal FERM-like domain of the focal adhesion kinase (FAK) as a negative regulator of its own activity and phosphorylation state. Deletion of the first 375 amino acids from the amino terminus of FAK increases its catalytic activity in vitro, its phosphoryl...

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Bibliographic Details
Main Authors: Cooper, Lee Ann, Shen, Tang-Long, Guan, Jun-Lin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC262338/
https://ncbi.nlm.nih.gov/pubmed/14585964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.22.8030-8041.2003
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