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Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

We have investigated a role for the amino-terminal FERM-like domain of the focal adhesion kinase (FAK) as a negative regulator of its own activity and phosphorylation state. Deletion of the first 375 amino acids from the amino terminus of FAK increases its catalytic activity in vitro, its phosphoryl...

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Udgivet i:Mol Cell Biol
Principais autores: Cooper, Lee Ann, Shen, Tang-Long, Guan, Jun-Lin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585964/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8030-8041.2003
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