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Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease

Resection is an early step in homology-directed recombinational repair (HDRR) of DNA double-strand breaks (DSBs). Resection enables strand invasion as well as reannealing following DNA synthesis across a DSB to assure efficient HDRR. While resection of only one end could result in genome instability...

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Detalhes bibliográficos
Main Authors: Westmoreland, James W., Resnick, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610664/
https://ncbi.nlm.nih.gov/pubmed/23555316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003420
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