Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.

The Rad50:Mre11:Xrs2 (RMX) complex functions in repair of DNA double-strand breaks (DSBs) by recombination and nonhomologous end-joining (NHEJ) and is also required for telomere stability. The Mre11 subunit exhibits nuclease activities in vitro, but the role of these activities in repair in mitotic...

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Detalhes bibliográficos
Main Authors: Lewis, L Kevin, Storici, Francesca, Van Komen, Stephen, Calero, Shanna, Sung, Patrick, Resnick, Michael A
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1470833/
https://ncbi.nlm.nih.gov/pubmed/15126391
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