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Cellular prion protein and Alzheimer disease: Link to oligomeric amyloid-β and neuronal cell death

Soluble oligomeric amyloid-β (Aβ) has been suggested to impair synaptic and neuronal function, leading to neurodegeneration that is clinically observed as the memory and cognitive dysfunction characteristic of Alzheimer disease, while the precise mechanism(s) whereby oligomeric Aβ causes neurotoxici...

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Bibliografiske detaljer
Main Authors: Kudo, Wataru, Petersen, Robert B., Lee, Hyoung-gon
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609115/
https://ncbi.nlm.nih.gov/pubmed/23154635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.22848
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