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DIGESTION PRODUCTS OF THE PH20 HYALURONIDASE INHIBIT REMYELINATION
OBJECTIVE: Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the failure of OPC maturation an...
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| Main Authors: | , , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608752/ https://ncbi.nlm.nih.gov/pubmed/23463525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23788 |
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