DIGESTION PRODUCTS OF THE PH20 HYALURONIDASE INHIBIT REMYELINATION

OBJECTIVE: Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the failure of OPC maturation an...

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Autori principali: Preston, Marnie, Gong, Xi, Su, Weiping, Matsumoto, Steven G., Banine, Fatima, Winkler, Clayton, Foster, Scott, Xing, Rubing, Struve, Jaime, Dean, Justin, Baggenstoss, Bruce, Weigel, Paul H., Montine, Thomas J., Back, Stephen A., Sherman, Larry S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608752/
https://ncbi.nlm.nih.gov/pubmed/23463525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23788
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