DIGESTION PRODUCTS OF THE PH20 HYALURONIDASE INHIBIT REMYELINATION

OBJECTIVE: Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA) accumulates in demyelinating lesions and has been implicated in the failure of OPC maturation an...

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Main Authors: Preston, Marnie, Gong, Xi, Su, Weiping, Matsumoto, Steven G., Banine, Fatima, Winkler, Clayton, Foster, Scott, Xing, Rubing, Struve, Jaime, Dean, Justin, Baggenstoss, Bruce, Weigel, Paul H., Montine, Thomas J., Back, Stephen A., Sherman, Larry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608752/
https://ncbi.nlm.nih.gov/pubmed/23463525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.23788
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