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Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils

PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition. Although ultimately not a component of mature fibrils, the PMEL N-terminal region (NTR...

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Detalhes bibliográficos
Main Authors: Leonhardt, Ralf M., Vigneron, Nathalie, Hee, Jia Shee, Graham, Morven, Cresswell, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608505/
https://ncbi.nlm.nih.gov/pubmed/23389629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-10-0742
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