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Melanosomal formation of PMEL core amyloid is driven by aromatic residues
PMEL is a pigment cell protein that forms physiological amyloid in melanosomes. Many amyloids and/or their oligomeric precursors are toxic, causing or contributing to severe, incurable diseases including Alzheimer’s and prion diseases. Striking similarities in intracellular formation pathways betwee...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341037/ https://ncbi.nlm.nih.gov/pubmed/28272432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44064 |
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