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Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL

The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyloid fragment (CAF) and perhaps additional parts of the protein, such as th...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Mitchell, Susan M., Graham, Morven, Liu, Xinran, Leonhardt, Ralf M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8032716/
https://ncbi.nlm.nih.gov/pubmed/33833328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-87259-y
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