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Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System

The study objective was to investigate factors that affect the central nervous system (CNS) distribution of elacridar. Elacridar inhibits transport mediated by P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) and has been used to study the influence of transporters on brain distribu...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Sane, Ramola, Agarwal, Sagar, Mittapalli, Rajendar K., Elmquist, William F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Pharmacology and Experimental Therapeutics 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608446/
https://ncbi.nlm.nih.gov/pubmed/23397054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.199786
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