A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines

Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole-genome loss-of-function screen to identify genes whose knockdown pot...

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Auteurs principaux: Singleton, Katherine R., Kim, Jihye, Hinz, Trista K., Marek, Lindsay A., Casás-Selves, Matias, Hatheway, Clark, Tan, Aik Choon, DeGregori, James, Heasley, Lynn E.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608435/
https://ncbi.nlm.nih.gov/pubmed/23371912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.084111
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