Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response

BACKGROUND: Epidermal growth factor receptor (EGFR) is frequently amplified or overexpressed in head and neck squamous cell carcinoma (HNSCC) and is a clinically validated target for the therapeutic antibody, cetuximab, in the management of this cancer. The degree of response to EGFR inhibitors meas...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Korpela, Sean P., Hinz, Trista K., Oweida, Ayman, Kim, Jihye, Calhoun, Jacob, Ferris, Robert, Nemenoff, Raphael A., Karam, Sana D., Clambey, Eric T., Heasley, Lynn E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825244/
https://ncbi.nlm.nih.gov/pubmed/33485341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02706-8
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